Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, 08903, USA. Department of Medical Oncology, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC, 28204, USA. Institute for Drug Development, Cancer Therapy and Research Center, University of Texas Health Science Center San Antonio, San Antonio, TX, 78229, USA. Department of Clinical Pharmacology and Translational Medicine, Eisai Inc., Woodcliff Lake, NJ, 07677, USA. Department of Clinical Pharmacology and Translational Medicine, Oncology, Eisai Inc., Woodcliff Lake, NJ, 07677, USA. Department of Biostatistics, Oncology, Eisai Inc., Woodcliff Lake, NJ, 07677, USA. Department of Oncology Clinical Development, Eisai Inc., Woodcliff Lake, NJ, 07677, USA. Department of Medical Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, 1695 Eastchester Road, Bronx, NY, 10461, USA. sgoel@montefiore.org.